Sung Hee Hwang Selected Research

4- (4- (3- adamantan- 1- ylureido)cyclohexyloxy)benzoic acid

12/2013	Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke.
1/2012	Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats.
8/2010	Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.
1/2010	Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury.
8/2007	Orally bioavailable potent soluble epoxide hydrolase inhibitors.

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Sung Hee Hwang Research Topics

Disease

31	Inflammation (Inflammations) 10/2021 - 01/2009
15	Neoplasms (Cancer) 10/2021 - 04/2007
12	Pain (Aches) 08/2021 - 04/2011
11	Hypertension (High Blood Pressure) 01/2021 - 01/2011
8	Fibrosis (Cirrhosis) 01/2021 - 01/2012
7	Neuralgia (Stump Neuralgia) 01/2021 - 07/2012
6	Neoplasm Metastasis (Metastasis) 10/2021 - 04/2007
4	Hepatocellular Carcinoma (Hepatoma) 01/2020 - 11/2011
4	Obesity 01/2020 - 01/2012
4	Parkinson Disease (Parkinson's Disease) 01/2019 - 01/2013
4	Carcinogenesis 02/2016 - 04/2013
3	Neuroinflammatory Diseases 12/2020 - 02/2018
3	Alzheimer Disease (Alzheimer's Disease) 12/2020 - 01/2012
3	Body Weight (Weight, Body) 01/2020 - 01/2012
3	Pancreatic Neoplasms (Pancreatic Cancer) 07/2019 - 04/2007
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 06/2013
3	Neuroblastoma 01/2019 - 01/2012
3	Myocardial Infarction 01/2019 - 12/2009
2	Cytokine Release Syndrome 10/2021 - 01/2020
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2021 - 01/2020
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021 - 01/2018
2	Ischemia 10/2020 - 01/2010
2	Reperfusion Injury 10/2020 - 01/2010
2	Non-alcoholic Fatty Liver Disease 01/2020 - 01/2019
2	Infections 01/2020 - 06/2013
2	Seizures (Absence Seizure) 01/2020 - 01/2013
2	Fatty Liver 01/2020 - 01/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 01/2012
2	Asthma (Bronchial Asthma) 01/2019 - 01/2015
2	Hypertrophy 01/2019 - 01/2012
2	Albuminuria 01/2019 - 01/2018
2	Respiratory Hypersensitivity 01/2019 - 01/2015
2	Necrosis 01/2016 - 01/2013
2	Infarction (Infarctions) 12/2013 - 01/2010
2	Cardiomegaly (Heart Hypertrophy) 04/2013 - 12/2009
2	Malignant Hypertension 02/2013 - 01/2011
2	Melanoma (Melanoma, Malignant) 01/2013 - 03/2008
1	Diabetic Nephropathies (Diabetic Nephropathy) 11/2021
1	Acute Pain 08/2021

Drug/Important Bio-Agent (IBA)

52	Epoxide HydrolasesIBA 11/2021 - 01/2009
19	AcidsIBA 01/2021 - 01/2010
9	LipidsIBA 01/2020 - 12/2009
9	EnzymesIBA 01/2019 - 08/2009
8	Arachidonic Acid (Vitamin F)IBA 01/2020 - 01/2013
7	Fatty Acids (Saturated Fatty Acids)IBA 01/2019 - 07/2012
6	Antihypertensive Agents (Antihypertensives)IBA 10/2020 - 01/2011
6	LipopolysaccharidesIBA 01/2020 - 08/2007
6	Benzoic Acid (Potassium Benzoate)FDA Link 01/2018 - 08/2007
5	CytokinesIBA 10/2021 - 01/2016
5	EicosanoidsIBA 10/2021 - 07/2014
5	dual inhibitor PTUPBIBA 01/2021 - 10/2017
5	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2021 - 07/2014
5	4- (4- (3- adamantan- 1- ylureido)cyclohexyloxy)benzoic acidIBA 12/2013 - 08/2007
4	Biological ProductsIBA 01/2021 - 12/2009
4	Sorafenib (BAY 43-9006)FDA Link 01/2021 - 08/2009
4	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2021 - 07/2014
4	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2013
4	gintoninIBA 10/2015 - 01/2012
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2021 - 01/2013
3	Epoxy Compounds (Epoxides)IBA 01/2021 - 03/2013
3	Urea (Carbamide)FDA LinkGeneric 12/2020 - 04/2011
3	Angiotensin IIIBA 01/2019 - 01/2011
3	Celecoxib (Celebrex)FDA Link 01/2019 - 01/2013
3	4- (4- (3- (4- trifluoromethoxy- phenyl)ureido)cyclohexyloxy)benzoic acidIBA 01/2019 - 01/2017
2	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 11/2021 - 07/2014
2	Enalapril FDA LinkGeneric 11/2021 - 10/2020
2	Analgesics (Analgesic Drugs)IBA 08/2021 - 01/2021
2	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2021 - 01/2018
2	Opioid Analgesics (Opioids)IBA 01/2021 - 07/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 08/2009
2	tetramethylenedisulfotetramine (DSTA)IBA 01/2020 - 06/2014
2	InflammasomesIBA 01/2020 - 01/2020
2	RodenticidesIBA 01/2020 - 06/2014
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2019 - 01/2016
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2019 - 02/2016
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2019 - 07/2014
2	RotenoneIBA 01/2019 - 02/2018
2	ProstaglandinsIBA 01/2019 - 07/2014
2	Pharmaceutical PreparationsIBA 01/2019 - 01/2013
2	AllergensIBA 01/2019 - 01/2018
2	LigandsIBA 01/2019 - 01/2012
2	11,12-epoxy-5,8,14-eicosatrienoic acidIBA 01/2017 - 01/2010
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2016 - 01/2016
2	CaspasesIBA 01/2015 - 04/2014
2	triphenyltetrazoliumIBA 12/2013 - 01/2010
2	indole-3-carbinolIBA 02/2013 - 01/2011
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2013 - 01/2012
2	Streptozocin (Streptozotocin)FDA Link 01/2013 - 07/2012
2	Glucose (Dextrose)FDA LinkGeneric 07/2012 - 01/2012
2	ReninIBA 06/2012 - 01/2011
2	Lysophosphatidic Acid ReceptorsIBA 02/2012 - 01/2012
2	DNA (Deoxyribonucleic Acid)IBA 11/2011 - 04/2007
1	Blood Glucose (Blood Sugar)IBA 11/2021
1	Dinoprostone (PGE2)FDA Link 10/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021

Therapy/Procedure

12	Therapeutics 10/2021 - 04/2007
6	Oral Administration 01/2018 - 01/2009
3	Drug Therapy (Chemotherapy) 10/2021 - 11/2011
2	Subcutaneous Injections 01/2021 - 01/2016
2	Surgical Instruments (Clip) 01/2012 - 06/2011